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KMID : 0360319720070010001
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Journal of Korean Cancer Research Association
1972 Volume.7 No. 1 p.1 ~ p.14
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A SYSTEMIC ANALYSIS OF OXIDATIVE PATHWAYS OF THE SUGAR IN TUMOR TISSUES
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정풍만/Jung PM
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Abstract
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In order to prove the derangement of the oxidative metabolism of sugar in cancer tissued, the oxidative pathway of glucose and its intermediates was analyzed xyxtematically with human and animal cancer tissued. The results were as follows: 1) Total CO2 production and RSACO2 of sugar were remarkably decreased in cancer tissues. 2) The fractionation of the oxidative pathway of glucose suggested that the decreased production of CO2 from glcose was due to the poor efficiency of the EMP-TCA cycle. 3) The carboxyl carbon of lactate was easily oxidized to CO2 but the oxidation of C-2 and C-3 was suppressed. This suggested that not same amount of CO2 was evolved from each earbon of sugar. Therefore, the following metabolic pattern of glcose was suggested as a common character in cancer tissues. Glucose uptaken by ancer tissues was degraded easily to 3 carbon compound via the anaerobic glycolytic pathway and C-1 of glucose could be easily oxidized to CO2 via the HMP. Further oxidation of 3 carbon compound was still able to be oxidized only for the C-1 by the oxidative decarboxylotion, but the oxidation of C-2 and C-3 of 3 carbon campound was remarkably suppressed. Those findings indicated that the incorporation of 2 carbon ompound into the TCA cycle was suppressed.
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